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For adults, the cutoff for serum holoTC, based on the relation of holoTC to serum methyl­malonic acid, is 12 mol/L), the association of total serum B12 levels with serum MMA (and tHcy) was explored with restricted cubic splines (Figure 22b.5)

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This results in the various features of scurvy including capillary fragility manifested as hemorrhagic processes, delayed wound healing, and bony abnormalities